There are several risk factors that could increase a person’s risk of developing colorectal polyps or colorectal cancer. Which of the following claim/s are/is true?1,2
Colorectal cancer is one of the most common cancer types in all Nordic countries. How many new cases of colorectal cancer were reported in Nordic countries in 2020?3
BRAFV600E mutation is one of the most critical mutations associated with metastatic colorectal cancer. Which of the following claim/s regarding BRAFV600E mutations is/are true?4-7
Colorectal cancer exhibits differences in incidence, pathogenesis, molecular pathways and outcome depending on the location of the tumour. It is suggested that there are biological differences between left-sided and right-sided colorectal cancers. Connect the side of the tumour and its typical manifestations.8-11
The highest risk of developing colorectal cancer is on people with a family history of colorectal cancer or inflammatory bowel diseases. Moderate risk factors for developing colorectal cancer are smoking tobacco and lifestyle-related factors (low physical activity, low intake of fruit and vegetables, and high intake of red meat). Having a risk factor, or even multiple, does not mean that disease will develop. On the other hand, some people who develop colorectal cancer may not have any known risk factors.
The estimated number of new cases of colorectal cancer in the Nordic countries in 2020 was 21,498. In the Nordic countries, the estimated cumulative risk of incidence is the highest in Denmark.
BRAF mutations (nearly always V600E) are found in the tumours of between 8% and 12% of patients with mCRC included in clinical trials and are almost exclusively non overlapping with RAS mutations. The mutation is often associated with a poor prognosis and does not usually respond well to chemotherapy. BRAF mutations (nearly always V600E) are found population- based in 20-21% of patients with mCRC.
Thank you for testing your knowledge on colorectal cancer!
You can find more information about colorectal cancer on our website. Our colorectal cancer awareness infographics and colorectal cancer patient atlas can be utilised when discussing colorectal cancer with your patient.